Applications are now being sought for a postdoctoral research position to study mechanisms by which mechanical forces control embryonic morphogenesis in the heart and its valves. Cornell University has a long history as a pioneering innovator of optical physics based technology for biomedical applications. Our team has developed novel multiphoton-guided photoablation technology to non-invasively perturb developing embryonic heart structures in live embryos, and quantitatively assess their downstream hemodynamic and biological response. We further have developed experimental tools directly measure the local changes in mechanical properties of embryonic soft tissues in situ, as well as computational analysis platforms to quantify these on a global scale. We integrate this information with more controlled mechanistic studies using engineered tissue models of morphogenesis, quantitatively analyzing the biological response on a number of length scales.
This NIH funded position will pursue one or more of the following broad research goals: 1) Elucidate the in vivo mechanobiological regulatory network governing embryonic heart morphogenesis via localized hemodynamic perturbation in vivo, 2) Determine the interrelationships between growth factor signaling and mechanical stimulation in the normal and abnormal development of cardiac tissues. 3) Integrate the global and local biomechanical and molecular datasets in developing embryonic hearts towards a multi-scale computational model of valve and/or outflow tract morphogenesis.
Ideal candidates should have a PhD or equivalent degree with experience in live animal imaging, computational modeling, and/or 3D culture mechanobiology. Experience with cardiovascular and/or developmental biology is a plus.
Interested candidates should forward a cover letter with a statement of their professional interests, a full CV and a list of three references with complete contact information to:
Jonathan Butcher, PhD
Meinig School of Biomedical Engineering
Cornell University, Ithaca, NY
Cornell University is located in the heart of the beautiful Finger Lakes region of upstate New York, known for its wines, craft beers, and unique blend of outdoors and cosmopolitan lifestyle. Cornell cherishes its diversity and is an equal opportunity employer.