Group News

Wednesday, October 23, 2019

The fall 2019 annual BME Newsletter includes an article highlighting student athletes in Prof. Butcher's fall 2019 BME 3410 Class. Read the article here.

Wednesday, April 10, 2019

Applications are now being sought for a postdoctoral research position to study mechanisms by which mechanical forces control embryonic morphogenesis in the heart and its valves. Cornell University has a long history as a pioneering innovator of optical physics based technology for biomedical applications. Our team has developed novel multiphoton-guided photoablation technology to non-invasively perturb developing embryonic heart structures in live embryos, and quantitatively assess their downstream hemodynamic and biological response. We further have developed experimental tools directly measure the local changes in mechanical properties of embryonic soft tissues in situ, as well as computational analysis platforms to quantify these on a global scale. We integrate this information with more controlled mechanistic studies using engineered tissue models of morphogenesis, quantitatively analyzing the biological response on a number of length scales.

This NIH funded position will pursue one or more of the following broad research goals: 1) Elucidate the in vivo mechanobiological regulatory network governing embryonic heart morphogenesis via localized hemodynamic perturbation in vivo, 2) Determine the interrelationships between growth factor signaling and mechanical stimulation in the normal and abnormal development of cardiac tissues. 3) Integrate the global and local biomechanical and molecular datasets in developing embryonic hearts towards a multi-scale computational model of valve and/or outflow tract morphogenesis.

Ideal candidates should have a PhD or equivalent degree with experience in live animal imaging, computational modeling, and/or 3D culture mechanobiology. Experience with cardiovascular and/or developmental biology is a plus.

Interested candidates should forward a cover letter with a statement of their professional interests, a full CV and a list of three references with complete contact information to:

Jonathan Butcher, PhD
jtb47@cornell.edu
Meinig School of Biomedical Engineering
Cornell University, Ithaca, NY

Cornell University is located in the heart of the beautiful Finger Lakes region of upstate New York, known for its wines, craft beers, and unique blend of outdoors and cosmopolitan lifestyle. Cornell cherishes its diversity and is an equal opportunity employer.

Tuesday, April 9, 2019

Applications are now being sought for a postdoctoral research position to study mechanisms by which mechanical forces coordinate heart valve homeostasis and disease pathogenesis. Our team has developed novel 3D in vitro engineered tissue models of heart valve tissues enabling mechanistic investigation of emergent multi-cellular phenomena. These include novel test beds for applying mechanical forces to complex 3D tissues as well as the ability to measure local anisotropic biomechanical changes during tissue remodeling. We also test these mechanisms in vivo with unique animal model systems and in human tissues. We have developed a rich collaborative network of molecular geneticists, computational biologists, and clinicians.

This is an NIH funded position that is further scaffolded by a variety of training grants in the space, as well as access to a unique blend of advanced engineering and life science technologies, intellectual expertise, and professional development resources. The lab is supported by grants from the NIH, NSF, and NY State. Our lab has trained and mentored over a half-dozen tenured and tenure track faculty in the US and overseas.

Ideal candidates should have a PhD or equivalent degree with experience in molecular biology, computational modeling, and/or 3D culture mechanobiology.

Interested candidates should forward a cover letter with a statement of their professional interests, a full CV and a list of three references with complete contact information to Interested candidates should forward a cover letter with a statement of their professional interests, a full CV and a list of three references with complete contact information to:

Jonathan Butcher, PhD
jtb47@cornell.edu
Meinig School of Biomedical Engineering
Cornell University, Ithaca, NY

Cornell University is located in the heart of the beautiful Finger Lakes region of upstate New York, known for its wines, craft beers, and unique blend of outdoors and cosmopolitan lifestyle. Cornell cherishes its diversity and is an equal opportunity employer.

Thursday, April 4, 2019

Jonathan inducted into AIMBE’s prestigious College of Fellows!

The American Institute for Medical and Biological Engineering (AIMBE) has announced the induction of Meinig School faculty Jonathan Butcher to its College of Fellows. Election to the AIMBE College of Fellows is among the highest professional distinctions accorded to a medical and biological engineer. The College of Fellows is comprised of the top two percent of medical and biological engineers. College membership honors those who have made outstanding contributions to "engineering and medicine research, practice, or education” and to "the pioneering of new and developing fields of technology, making major advancements in traditional fields of medical and biological engineering, or developing/implementing innovative approaches to bioengineering education."

Jonathan was nominated, reviewed, and elected by peers and members of the College of Fellows for "pioneering the emerging field of heart valve mechanobiology by combining cardiovascular tissue mechanics with paradigms from developmental biology."

Friday, January 25, 2019

Butcher lab alum Russ Gould’s paper on bicuspid aortic valve genetics published in Nature Genetics (article).
Butcher lab alum Russ Gould'spaper, "ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm," published in Nature Genetics.

Thursday, January 10, 2019

Butcher lab alums Jessica Ryvlin and Stephanie Lindsey’s paper published in Anatomical Record
Butcher lab alums Jessica Ryvlin and Stephanie Lindsey’s paper, "Systematic Analysis of the Smooth Muscle Wall Phenotype of the Pharyngeal Arch Arteries During Their Reorganization into the Great Vessels and Its Association with Hemodynamics," published in Anatomical Record. (article)

Saturday, January 5, 2019

PhD student Guy Scuderi is awarded a Vertebrate Genomics Training fellowship

Saturday, December 8, 2018

PhD student Leah Pagnozzi is awarded a Provost Diversity Fellowship. 

Saturday, November 10, 2018

PhD student David Bassen awarded an INTERN fellowship from the NSF

Tuesday, October 23, 2018

Butcher lab alum Joe Yu’s paper on the biomechanics of cardiac regeneration is published in Scientific Reports.
Publication: "Cardiac regeneration following cryoinjury in the adult zebrafish targets a maturation-specific biomechanical remodeling program." (article)

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