Developmental Redux of Adult Valve Disease

Frendl CM, Tucker SM, Khan NA, Esch MB, Kanduru S, Cao TM, García AJ, King MR, Butcher JT.
Biomaterials. 2014 Sep;35(27):7714-23. doi: 10.1016/j.biomaterials.2014.05.075. Epub 2014 Jun 20. PMID: 24952977
Mahler GJ, Frendl CM, Cao Q, Butcher JT.
Biotechnol Bioeng. 2014 Nov;111(11):2326-37. doi: 10.1002/bit.25291. Epub 2014 Aug 5. PMID: 24898772
Zhou J, Bowen C, Lu G, Knapp Iii C, Recknagel A, Norris RA, Butcher JT.
Cells Tissues Organs. 2013;198(4):300-10. doi: 10.1159/000356762. Epub 2013 Dec 20.

Valvular endothelial cells inhibit calcification of valvular interstitial cells in mechanically stressed 3D culture.
Richards, J., Eli-Hamamsy, I., Chen, S., Yacoub, M.H., Chester, A.H., and Butcher. J.T.
American Journal of Pathology May;182(5):1922-31.

Inflammatory cytokines induce endothelial to mesenchymal transformation in valve endothelial cells via Akt/NFkB.
Mahler, G.J., Farrar, E., and Butcher, J.T.
Arteriosclerosis, Thrombosis, and Vascular Biology 2013 Jan;33(1):121-30.

Multi-scale Biomechanical Remodeling in Aging and Genetic Mutant Murine Mitral Valve Leaflets: Insights into Marfan Syndrome.
Gould, R., Sinha, R., Aziz, H., Rouf, R., Deitz, H., Judge, D., and Butcher, J.T.
PLoS One. 2012;7(9):e44639.

Cyclic strain anisotropy regulates valvular interstitial cell phenotype and tissue remodeling in three-dimensional culture
Gould RA, Chin K, Santisakultarm TP, Dropkin A, Richards JM, Schaffer CB, Butcher JT. Acta Biomaterialia
Interactions between TGFβ1 and cyclic strain in modulation of myofibroblastic differentiation of canine mitral valve interstitial cells in 3D culture
Waxman AS, Kornreich BG, Gould RA, Moise SN, Butcher JT. Journal of Veterinary Cardiology

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