Developmental Redux of Adult Valve Disease

JM Richards, I El-Hamamsy, S Chen, Z Sarang, P Sarathchandra, MH Yacoub, AH Chester, and JT Butcher. Am J Path
Mechanobiology of the aortic valve 
Butcher JT, Simmons CA, Warnock JN. Journal of Heart Valve Disease 
Metzler SA, Pregonero CA, Butcher JT, Burgess SC, Warnock JN. Journal of Heart Valve Disease
Equibiaxial strain stimulates fibroblastic phenotype shift in smooth muscle cells in an engineered tissue model of the aortic wall 
Butcher JT, Barrett BC, Nerem RM. Biomaterials
Valvular endothelial cells regulate the phenotype of interstitial cells in co-culture: effects of steady shear stress
Butcher JT, Nerem RM. Tissue Engineering
Transcriptional profiles of valvular and vascular endothelial cells reveals phenotypic differences: influence of shear stress
Butcher JT, Tressel S, Johnson T, Turner D, Sorescu G, Jo H, Nerem RM. Arteriosclerosis, Thrombosis, and Vascular Biology
Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments
Butcher JT, Penrod AM, Garcia AJ, Nerem RM. Arteriosclerosis, Thrombosis, and Vascular Biology

Porcine aortic valve interstitial cells in three-dimensional culture: comparison of phenotype with aortic smooth muscle cells 
Butcher JT, Nerem RM. Journal of Heart Valve Disease

Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH; Leducq Mitral Transatlantic Network.
Nat Rev Cardiol. 2015 Dec;12(12):689-710. doi: 10.1038/nrcardio.2015.161. Epub 2015 Oct 20. Review. PMID: 26483167

Endothelial-derived oxidative stress drives myofibroblastic activation and calcification of the aortic valve.
Farrar, E.J.; Huntley, G.D., and Butcher, J.T.
PLoS One. 2015 Apr 13;10(4):e0123257

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